Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma.

Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma.

BACKGROUND:Tobacco and alcohol consumption are risk factors for head and neck squamous cell carcinoma (HNSCC). Recently, whole-exome sequencing clarified that smoking increased TP53 and other mutations in HNSCC; however, the effects of alcohol consumption on these genetic alterations remain unknown....

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Main Authors: Mitsuyoshi Urashima, Takanori Hama, Toshihito Suda, Yutaka Suzuki, Masahiro Ikegami, Chikako Sakanashi, Taisuke Akutsu, Suguru Amagaya, Kazuhumi Horiuchi, Yu Imai, Hidetoshi Mezawa, Miki Noya, Akio Nakashima, Aki Mafune, Takakuni Kato, Hiromi Kojima
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3835411?pdf=render

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http://europepmc.org/articles/PMC3835411?pdf=render

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