Controlled Reperfusion Strategies Improve Cardiac Hemodynamic Recovery after Warm Global Ischemia in an Isolated, Working Rat Heart Model of Donation after Circulatory Death (DCD)

Controlled Reperfusion Strategies Improve Cardiac Hemodynamic Recovery after Warm Global Ischemia in an Isolated, Working Rat Heart Model of Donation after Circulatory Death (DCD)

Aims: Donation after circulatory death (DCD) could improve cardiac graft availability, which is currently insufficient to meet transplant demand. However, DCD organs undergo an inevitable period of warm ischemia and most cardioprotective approaches can only be applied at reperfusion (procurement) fo...

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Bibliographic Details
Main Authors: Emilie Farine, Petra Niederberger, Rahel K Wyss, Natalia Méndez Carmona, Brigitta Gahl, Martin G Fiedler, Thierry Carrel, Hendrik Tevaearai Stahel, Sarah Longnus
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Physiology
Subjects:
Heart Transplantation
hypoxia
Cardioprotection
ischemia reperfusion injury
Mild hypothermia
Donation after circulatory death
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00543/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00543/full

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