Effect of p53 activation through targeting MDM2/MDM4 heterodimer on T regulatory and effector cells in the peripheral blood of Type 1 diabetes patients.

Effect of p53 activation through targeting MDM2/MDM4 heterodimer on T regulatory and effector cells in the peripheral blood of Type 1 diabetes patients.

Various immunotherapies for the treatment of type 1 diabetes are currently under investigation. Some of these aim to rescue the remaining beta cells from autoimmune attack caused by the disease. Among the strategies employed, p53 has been envisaged as a possible target for immunomodulation. We studi...

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Bibliographic Details
Main Authors: Marsha Pellegrino, Gianandrea Traversi, Andrea Arena, Marco Cappa, M Manuela Rosado, Marco Andreani, Domenico V Delfino, Fabiola Moretti, Alessandra Fierabracci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0228296

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https://doi.org/10.1371/journal.pone.0228296

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