P-glycoprotein dysfunction contributes to hepatic steatosis and obesity in mice.

P-glycoprotein dysfunction contributes to hepatic steatosis and obesity in mice.

Although the main role of P-glycoprotein (Pgp) is to extrude a broad range of xenochemicals and to protect the organism against xenotoxicity, it also transports a large range of endogenous lipids. Using mice lacking Pgp, we have investigated the possible involvement of Pgp in lipid homeostasis in vi...

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Bibliographic Details
Main Authors: Magali Foucaud-Vignault, Zeina Soayfane, Cécile Ménez, Justine Bertrand-Michel, Pascal Guy Pierre Martin, Hervé Guillou, Xavier Collet, Anne Lespine
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3174940?pdf=render

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http://europepmc.org/articles/PMC3174940?pdf=render

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