A speedy route to sterically encumbered, benzene-fused derivatives of privileged, naturally occurring hexahydropyrrolo[1,2-b]isoquinoline

A speedy route to sterically encumbered, benzene-fused derivatives of privileged, naturally occurring hexahydropyrrolo[1,2-b]isoquinoline

A series of 15 benzene-fused hexahydropyrrolo[1,2-b]isoquinolonic acids with substantial degree of steric encumbrance has been prepared via a novel variant of the Castagnoli–Cushman reaction of homophthalic anhydride (HPA) and various indolenines. The employment of a special kind of a cyclic imine c...

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Bibliographic Details
Main Authors: Olga Bakulina, Alexander Ivanov, Vitalii Suslonov, Dmitry Dar’in, Mikhail Krasavin
Format: Article
Language:English
Published: Beilstein-Institut 2017-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Castagnoli–Cushman reaction
diastereoselectivity
homophthalic anhydride
indolenines
lactam synthesis
multicomponent reactions
Online Access:https://doi.org/10.3762/bjoc.13.138

Internet

https://doi.org/10.3762/bjoc.13.138

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