INCREASING SENSITIVITY OF MCF-7/DOX CELLS TOWARDS DOXORUBICIN BY HESPERETIN THROUGH SUPPRESSION OF P-GLYCOPROTEIN EXPRESSION

INCREASING SENSITIVITY OF MCF-7/DOX CELLS TOWARDS DOXORUBICIN BY HESPERETIN THROUGH SUPPRESSION OF P-GLYCOPROTEIN EXPRESSION

Long-term use of doxorubicin causes cancer resistance due to overexpression of P-glycoprotein (P-gp), a protein that plays a role in cell drug efflux. The purpose of this study is to determine the action of hesperetin in increasing the cytotoxicity of doxorubicin on MCF-7 cancer cells resistant...

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Bibliographic Details
Main Authors: Sarmoko, Dyaningtyas Dewi Pamungkas Putri, Ratna Asmah Susidarti, Agung Endro Nugroho, Edy Meiyanto
Format: Article
Language:English
Published: Universitas Gadjah Mada 2014-04-01
Series:Indonesian Journal of Pharmacy
Subjects:
Breast cancer
doxorubicin
resistance
hesperetin
Pglycoprotein
Online Access:http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/259

Internet

http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/259

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