ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling

ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling

Upon membrane depolarization, the KCNQ1 potassium channel opens at the intermediate (IO) and activated (AO) states of the stepwise voltage-sensing domain (VSD) activation. In the heart, KCNQ1 associates with KCNE1 subunits to form IKs channels that regulate heart rhythm. KCNE1 suppresses the IO stat...

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Bibliographic Details
Main Authors: Panpan Hou, Jingyi Shi, Kelli McFarland White, Yuan Gao, Jianmin Cui
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
VSD-pore coupling
KCNQ1 channel
ML277
state-dependent activation
long QT syndrome
activated open state
Online Access:https://elifesciences.org/articles/48576

Internet

https://elifesciences.org/articles/48576

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