Hydantoins: Synthesis, properties and anticonvulsant activity

• Main Authors: Trišović Nemanja P., Ušćumlić Gordana S., Petrović Slobodan D.
• Format: Article
• Language: English
• Published: Association of Chemical Engineers of Serbia 2009-01-01
• Series: Hemijska Industrija
• Subjects: hydantoin; properties; reactivity; synthesis; phenytoin; anticonvulsant activity; pharmacofor model; lipophilicity; hydrogen bonding
• Online Access: http://www.doiserbia.nb.rs/img/doi/0367-598X/2009/0367-598X0901017T.pdf

Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.