The role of exosomal PD-L1 in tumor progression and immunotherapy

The role of exosomal PD-L1 in tumor progression and immunotherapy

Abstract Programmed death ligand 1 (PD-L1), a type I transmembrane protein, binds to its receptor PD-1 to suppress the activation of T cells, thereby maintaining immunological homeostasis. In contrast, tumor cells highly express PD-L1, which binds to receptor PD-1 expressed on activated T cells, lea...

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Bibliographic Details
Main Authors: Feiting Xie, Mengxue Xu, Jian Lu, Lingxiang Mao, Shengjun Wang
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Molecular Cancer
Subjects:
Exosomes
PD-L1
PD-1
Tumor immunity
Biomarker
Online Access:http://link.springer.com/article/10.1186/s12943-019-1074-3

Internet

http://link.springer.com/article/10.1186/s12943-019-1074-3

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