Disseminated Melanoma Cells Transdifferentiate into Endothelial Cells in Intravascular Niches at Metastatic Sites

Disseminated Melanoma Cells Transdifferentiate into Endothelial Cells in Intravascular Niches at Metastatic Sites

Summary: Tumor cell plasticity, including transdifferentiation, is thought to be a key driver of therapy failure, tumor dormancy, and metastatic dissemination. Although melanoma cells have been shown to adopt various phenotypic features in vitro, direct in vivo evidence of metastatic cell plasticity...

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Bibliographic Details
Main Authors: Xiaoshuang Li, Panagiotis Karras, Raúl Torres, Florian Rambow, Joost van den Oord, Jean-Christophe Marine, Lidia Kos
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
melanoma metastasis
melanoma mouse model
dormant niche
tumor-derived endothelial cells
tumor vasculature
endothelial-mesenchymal transition
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720307452

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http://www.sciencedirect.com/science/article/pii/S2211124720307452

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