N′1,N′3-Dimethyl-N′1,N′3-bis(phenylcarbonothioyl) Propanedihydrazide (Elesclomol) Selectively Kills Cisplatin Resistant Lung Cancer Cells through Reactive Oxygen Species (ROS)

N′1,N′3-Dimethyl-N′1,N′3-bis(phenylcarbonothioyl) Propanedihydrazide (Elesclomol) Selectively Kills Cisplatin Resistant Lung Cancer Cells through Reactive Oxygen Species (ROS)

Cisplatin is an important chemotherapeutic agent in lung cancer treatment. The mechanism of drug resistance to cisplatin is complex and historically has been difficult to overcome. We report here that cisplatin resistant lung cancer cell lines possess high basal levels of reactive oxygen species (RO...

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Bibliographic Details
Main Authors: Niramol Savaraj, Lynn G. Feun, Vy Dinh, Johnathan C. Maher, Min You, Chunjing Wu, Medhi Wangpaichitr
Format: Article
Language:English
Published: MDPI AG 2009-12-01
Series:Cancers
Subjects:
lung cancer
drug resistant
cisplatin
ROS
elesclomol
Online Access:http://www.mdpi.com/2072-6694/1/1/23/

Internet

http://www.mdpi.com/2072-6694/1/1/23/

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