An iterative computational design approach to increase the thermal endurance of a mesophilic enzyme

An iterative computational design approach to increase the thermal endurance of a mesophilic enzyme

Abstract Background Strategies for maximizing the microbial production of bio-based chemicals and fuels include eliminating branched points to streamline metabolic pathways. While this is often achieved by removing key enzymes, the introduction of nonnative enzymes can provide metabolic shortcuts, b...

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Bibliographic Details
Main Authors: Deanne W. Sammond, Noah Kastelowitz, Bryon S. Donohoe, Markus Alahuhta, Vladimir V. Lunin, Daehwan Chung, Nicholas S. Sarai, Hang Yin, Ashutosh Mittal, Michael E. Himmel, Adam M. Guss, Yannick J. Bomble
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Biotechnology for Biofuels
Subjects:
Computational protein design
Biofuels
Thermal stability
Pyruvate decarboxylase
Online Access:http://link.springer.com/article/10.1186/s13068-018-1178-9

Internet

http://link.springer.com/article/10.1186/s13068-018-1178-9

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