Predicting inadequate postoperative pain management in depressed patients: A machine learning approach.

Predicting inadequate postoperative pain management in depressed patients: A machine learning approach.

Widely-prescribed prodrug opioids (e.g., hydrocodone) require conversion by liver enzyme CYP-2D6 to exert their analgesic effects. The most commonly prescribed antidepressant, selective serotonin reuptake inhibitors (SSRIs), inhibits CYP-2D6 activity and therefore may reduce the effectiveness of pro...

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Bibliographic Details
Main Authors: Arjun Parthipan, Imon Banerjee, Keith Humphreys, Steven M Asch, Catherine Curtin, Ian Carroll, Tina Hernandez-Boussard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0210575

Internet

https://doi.org/10.1371/journal.pone.0210575

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