Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly

Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly

Numerous proteins target lipid droplets (LDs) through amphipathic helices (AHs). It is generally assumed that AHs insert bulky hydrophobic residues in packing defects at the LD surface. However, this model does not explain the targeting of perilipins, the most abundant and specific amphipathic prote...

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Bibliographic Details
Main Authors: Manuel Giménez-Andrés, Tadej Emeršič, Sandra Antoine-Bally, Juan Martin D'Ambrosio, Bruno Antonny, Jure Derganc, Alenka Čopič
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
lipid droplet
perilipin 4
amphipathic helix
adipocyte
apolipoprotein
lipid droplet size
Online Access:https://elifesciences.org/articles/61401

Internet

https://elifesciences.org/articles/61401

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