Inhibition of histone deacetylase 6 suppresses inflammatory responses and invasiveness of fibroblast-like-synoviocytes in inflammatory arthritis

Inhibition of histone deacetylase 6 suppresses inflammatory responses and invasiveness of fibroblast-like-synoviocytes in inflammatory arthritis

Abstract Background To investigate the effects of inhibiting histone deacetylase (HDAC) 6 on inflammatory responses and tissue-destructive functions of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). Methods FLS from RA patients were activated with interleukin (IL)-1β in the presenc...

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Bibliographic Details
Main Authors: Jin Kyun Park, Sehui Shon, Hyun Jung Yoo, Dong-Hyeon Suh, Daekwon Bae, Jieun Shin, Jae Hyun Jun, Nina Ha, Hyeseung Song, Young Il Choi, Thomas Pap, Yeong Wook Song
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Arthritis Research & Therapy
Subjects:
Histone deacetylase 6
Inhibitor
Rheumatoid arthritis
Inflammation
Fibroblast-like synoviocytes
Online Access:https://doi.org/10.1186/s13075-021-02561-4

Internet

https://doi.org/10.1186/s13075-021-02561-4

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