Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

Macrophages are professional immune cells that ingest and kill microbes. In this study, we show that different pathogenic bacteria induce the expression of cystathionine γ-lyase (CTH) in macrophages. This enzyme is involved in a metabolic pathway called the reverse transsulfuration pathway, which le...

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Bibliographic Details
Main Authors: Alain P. Gobert, Yvonne L. Latour, Mohammad Asim, Jordan L. Finley, Thomas G. Verriere, Daniel P. Barry, Ginger L. Milne, Paula B. Luis, Claus Schneider, Emilio S. Rivera, Kristie Lindsey-Rose, Kevin L. Schey, Alberto G. Delgado, Johanna C. Sierra, M. Blanca Piazuelo, Keith T. Wilson
Format: Article
Language:English
Published: American Society for Microbiology 2019-10-01
Series:mBio
Subjects:
helicobacter pylori
immune evasion
immunometabolism
innate immunity
macrophages
pathogenic bacteria
polyamines
Online Access:https://doi.org/10.1128/mBio.02174-19

Internet

https://doi.org/10.1128/mBio.02174-19

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