TAT-Bcl-xL improves survival of neuronal precursor cells in the lesioned striatum after focal cerebral ischemia

TAT-Bcl-xL improves survival of neuronal precursor cells in the lesioned striatum after focal cerebral ischemia

Cerebral ischemia activates endogenous neurogenesis in the subventricular zone (SVZ) and the dentate gyrus. Consecutively, SVZ-derived neural precursors migrate towards ischemic lesions. However, functional relevance of activated neurogenesis is limited by poor survival of new-born precursors. We th...

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Bibliographic Details
Main Authors: Thorsten R. Doeppner, Gunnar P.H. Dietz, Mimount El Aanbouri, Joachim Gerber, Otto W. Witte, Mathias Bähr, Jens Weise
Format: Article
Language:English
Published: Elsevier 2009-04-01
Series:Neurobiology of Disease
Subjects:
Cerebral ischemia
Endogenous neurogenesis
Neuroprotection
TAT fusion proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108003173

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http://www.sciencedirect.com/science/article/pii/S0969996108003173

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