Biosynthesis of Circular RNA ciRS-7/CDR1as Is Mediated by Mammalian-wide Interspersed Repeats

Summary: Circular RNAs (circRNAs) are stable non-coding RNAs with a closed circular structure. One of the best studied circRNAs is ciRS-7 (CDR1as), which acts as a regulator of the microRNA miR-7; however, its biosynthetic pathway has remained an enigma. Here we delineate the biosynthetic pathway of...

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Bibliographic Details
Main Authors: Rei Yoshimoto, Karim Rahimi, Thomas B. Hansen, Jørgen Kjems, Akila Mayeda
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220305320