Synthesis and Pharmacological Evaluation of Novel 1-(1,4-Alkylaryldisubstituted-4,5-dihydro-1H-imidazo)-3-substituted Urea Derivatives

Synthesis and Pharmacological Evaluation of Novel 1-(1,4-Alkylaryldisubstituted-4,5-dihydro-1H-imidazo)-3-substituted Urea Derivatives

Novel 1-(1,4-alkylaryldisubstituted-4,5-dihydro-1H-imidazo)-3-substituted urea derivatives have been synthesized and evaluated for their central nervous system activity. Compounds 3a–m were prepared in the reaction between the respective 1-alkyl-4-aryl-4,5-dihydro-1H-imidazol-2-amines 1a–c and appro...

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Bibliographic Details
Main Authors: Elżbieta Szacoń, Marzena Rządkowska, Agnieszka A. Kaczor, Ewa Kędzierska, Jolanta Orzelska-Górka, Sylwia Fidecka, Dariusz Matosiuk
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Molecules
Subjects:
1-alkyl-4-aryl-4,5-dihydro-1H-imidazo-2-amines
antinociceptive compounds
central nervous system (CNS) activity
in silico ADMET studies
Online Access:http://www.mdpi.com/1420-3049/21/5/582

Internet

http://www.mdpi.com/1420-3049/21/5/582

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