General Pathway for a Convenient One-Pot Synthesis of Trifluoromethyl-Containing 2-amino-7-alkyl(aryl/heteroaryl)-1,8-naphthyridines and Fused Cycloalkane Analogues

General Pathway for a Convenient One-Pot Synthesis of Trifluoromethyl-Containing 2-amino-7-alkyl(aryl/heteroaryl)-1,8-naphthyridines and Fused Cycloalkane Analogues

A convenient and general method for the synthesis in 26–73% yields of a new series of 7-alkyl(aryl/heteroaryl)-2-amino-5-trifluoromethyl-1,8-naphthyridines from direct cyclocondensation reactions of 4-alkoxy-1,1,1-trifluoroalk-3-en-2-ones [CF3C(O)CH=C(R1)OR, where R1 = H, Me, Ph, 4-MePh, 4-OMePh, 4-...

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Bibliographic Details
Main Authors: Marcos A. P. Martins, Nilo Zanatta, Nícolas Krüger, Rosália Andrighetto, Helio G. Bonacorso
Format: Article
Language:English
Published: MDPI AG 2011-03-01
Series:Molecules
Subjects:
trifluoromethylated heterocyles
quinolines
naphthyridines
cycloalka[b][1,8]-naphthyridines
aminonaphthyridines
Online Access:http://www.mdpi.com/1420-3049/16/4/2817/

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http://www.mdpi.com/1420-3049/16/4/2817/

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