Cross-protective immunity to Leishmania amazonensis is mediated by CD4+ and CD8+-epitopes of Leishmania donovani Nucleoside Hydrolase terminal domains

Cross-protective immunity to Leishmania amazonensis is mediated by CD4+ and CD8+-epitopes of Leishmania donovani Nucleoside Hydrolase terminal domains

The Nucleoside hydrolase of Leishmania donovani (NH36) is a phylogenetic marker of high homology among Leishmania parasites. In mice and dog vaccination NH36 induces a CD4+ T cell-driven protective response against Leishmania chagasi infection directed against its C-terminal domain (F3). The C-termi...

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Bibliographic Details
Main Authors: Dirlei eNico, Daniele Crespo Gomes, Marcus Vinícus Alves-Silva, Elisangela Oliveira Freitas, Alexandre eMorrot, Diana eBahia, Marcos ePalatnik, Mauricio Martins eRodrigues, Clarisa B. Palatnik-De-Sousa
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Immunology
Subjects:
Visceral leishmaniasis
cutaneous leishmaniasis
prophylaxis
cross-protection
diffuse cutaneous leishmaniasis
Nucleoside hydrolases
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00189/full

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http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00189/full

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