Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection

Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection

Single-cell transcriptomics was used to profile cells of the normal murine middle ear. Clustering analysis of 6770 transcriptomes identified 17 cell clusters corresponding to distinct cell types: five epithelial, three stromal, three lymphocyte, two monocyte, two endothelial, one pericyte and one me...

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Bibliographic Details
Main Authors: Allen F. Ryan, Chanond A. Nasamran, Kwang Pak, Clara Draf, Kathleen M. Fisch, Nicholas Webster, Arwa Kurabi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Genetics
Subjects:
single-cell
middle ear
otitis media
cluster-profiling
homeostasis
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00358/full

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