Measuring Intratumoral Heterogeneity of Immune Repertoires

Measuring Intratumoral Heterogeneity of Immune Repertoires

There is considerable clinical and fundamental value in measuring the clonal heterogeneity of T and B cell expansions in tumors and tumor-associated lymphoid structures—along with the associated heterogeneity of the tumor neoantigen landscape—but such analyses remain challenging to perform. Here, we...

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Main Authors: Diana Vladimirovna Yuzhakova, Lilia N. Volchkova, Mikhail Valerievich Pogorelyy, Ekaterina O. Serebrovskaya, Irina A. Shagina, Ekaterina A. Bryushkova, Tatiana O. Nakonechnaya, Anna V. Izosimova, Daria S. Zavyalova, Maria M. Karabut, Mark Izraelson, Igor V. Samoylenko, Vladimir E. Zagainov, Dmitriy M. Chudakov, Elena V. Zagaynova, George Vladimirovich Sharonov
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
tumour heterogeneity
clonal expansions
tumour clonality
TCR repertoire
immunoglobulin repertoire
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00512/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00512/full

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