Osimertinib Did Not Respond to a Pulmonary Adenocarcinoma with Triple Mutations of Epidermal Growth Factor Receptor, G719S, T790M and S768I

Uncommon epidermal growth factor receptor (EGFR) gene mutations include G719S, T790M and S768I. T790M gatekeeper mutation is the most frequent mechanism of acquired drug resistance to first- and second-generation EGFR-tyrosine kinase inhibitors (TKIs). Osimertinib is a specific EGFR-TKI to overcome...

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Bibliographic Details
Main Authors: Seigo Minami, Shouichi Ihara, Tsunehiro Tanaka, Hideyasu Okada, Kazuki Hashimoto, Kiyoshi Komuta
Format: Article
Language:English
Published: Karger Publishers 2019-02-01
Series:Case Reports in Oncology
Subjects:
Online Access:https://www.karger.com/Article/FullText/497316