NLRP3 Deficiency Protects Against Intermittent Hypoxia-Induced Neuroinflammation and Mitochondrial ROS by Promoting the PINK1-Parkin Pathway of Mitophagy in a Murine Model of Sleep Apnea

NLRP3 Deficiency Protects Against Intermittent Hypoxia-Induced Neuroinflammation and Mitochondrial ROS by Promoting the PINK1-Parkin Pathway of Mitophagy in a Murine Model of Sleep Apnea

Obstructive sleep apnea (OSA) associated neurocognitive impairment is mainly caused by chronic intermittent hypoxia (CIH)-triggered neuroinflammation and oxidative stress. Previous study has demonstrated that mitochondrial reactive oxygen species (mtROS) was pivotal for hypoxia-related tissue injury...

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Bibliographic Details
Main Authors: Xu Wu, Linjing Gong, Liang Xie, Wenyu Gu, Xinyuan Wang, Zilong Liu, Shanqun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
obstructive sleep apnea (OSA)
neuroinflammation
nucleotide‐binding domain like receptor protein 3 (NLRP3)
reactive oxygen species (ROS)
parkin-mediated mitophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.628168/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.628168/full

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