Caspase-1 activity affects AIM2 speck formation/ stability through a negative feedback loop.

Caspase-1 activity affects AIM2 speck formation/ stability through a negative feedback loop.

The inflammasome is an innate immune signaling platform leading to caspase-1 activation, maturation of pro-inflammatory cytokines and cell death. Recognition of DNA within the host cytosol induces the formation of a large complex composed of the AIM2 receptor, the ASC adaptor and the caspase-1 effec...

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Bibliographic Details
Main Authors: Carole eJuruj, Virginie eLelogeais, Roberto ePierini, Magali ePerret, Bénédicte F Py, Yvan eJamilloux, Petr eBroz, Florence eAder, Mathias eFaure, Thomas eHenry
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Francisella tularensis
regulation
Inflammasome
AIM2
caspase-1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00014/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00014/full

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