Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity

Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity

Background: Insulin plays a pivotal role in the regulation of both carbohydrate and lipid intermediate turnover and metabolism. In the transition from a fasted to fed state, insulin action inhibits lipolysis in adipocytes, and acylcarnitine synthesis in the muscles and heart. The aim of this study w...

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Bibliographic Details
Main Authors: Elina Makarova, Marina Makrecka-Kuka, Karlis Vilks, Kristine Volska, Eduards Sevostjanovs, Solveiga Grinberga, Olga Zarkova-Malkova, Maija Dambrova, Edgars Liepinsh
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Endocrinology
Subjects:
glucose tolerance test
insulin resistance
long-chain acylcarnitines
free fatty acids
type 2 diabetes
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00870/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00870/full

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