Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production

Hypothalamic melanocortin neurons regulate systemic glucose homeostasis through incompletely understood pathways. Here, the authors show that a subset of pro-opiomelanocortin neurons innervate the liver via preganglionic parasympathetic cholinergic neurons in the dorsal motor nucleus of the vagus an...

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Bibliographic Details
Main Authors: Eunjin Kwon, Hye-Young Joung, Shun-Mei Liu, Streamson C. Chua, Gary J. Schwartz, Young-Hwan Jo
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20160-w