A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68Ga-DOTATATE in patients without neuroendocrine tumors

A physiologically based pharmacokinetic (PBPK) model to describe organ distribution of 68Ga-DOTATATE in patients without neuroendocrine tumors

Abstract Background Physiologically based pharmacokinetic (PBPK) models combine drug-specific information with prior knowledge on the physiology and biology at the organism level. Whole-body PBPK models contain an explicit representation of the organs and tissue and are a tool to predict pharmacokin...

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Bibliographic Details
Main Authors: H. Siebinga, B. J. de Wit-van der Veen, J. H. Beijnen, M. P. M. Stokkel, T. P. C. Dorlo, A. D. R. Huitema, J. J. M. A. Hendrikx
Format: Article
Language:English
Published: SpringerOpen 2021-08-01
Series:EJNMMI Research
Subjects:
PBPK modeling
Whole-body distribution
68Ga-DOTATATE
PRRT
Peptide amount
SSTR2
Online Access:https://doi.org/10.1186/s13550-021-00821-7

Internet

https://doi.org/10.1186/s13550-021-00821-7

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