Matrix metalloproteinase-2-induced epidermal growth factor receptor transactivation impairs redox balance in vascular smooth muscle cells and facilitates vascular contraction

Matrix metalloproteinase-2-induced epidermal growth factor receptor transactivation impairs redox balance in vascular smooth muscle cells and facilitates vascular contraction

Increased reactive oxygen species (ROS) formation may enhance matrix metalloproteinase (MMP)-2 activity and promote cardiovascular dysfunction. We show for the first time that MMP-2 is upstream of increased ROS formation and activates signaling mechanisms impairing redox balance. Incubation of vascu...

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Bibliographic Details
Main Authors: Alejandro F. Prado, Laena Pernomian, Aline Azevedo, Rute A.P. Costa, Elen Rizzi, Junia Ramos, Adriana F. Paes Leme, Lusiane M. Bendhack, Jose E. Tanus-Santos, Raquel F. Gerlach
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718305214

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http://www.sciencedirect.com/science/article/pii/S2213231718305214

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