Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4+CD25+ regulatory T cells.

Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4+CD25+ regulatory T cells.

BACKGROUND: Heat shock proteins (Hsps) are stress induced proteins with immunomodulatory properties. The Hsp70 of Mycobacterium tuberculosis (TBHsp70) has been shown to have an anti-inflammatory role on rodent autoimmune arthritis models, and the protective effects were demonstrated to be dependent...

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Main Authors: Thiago J Borges, Bárbara N Porto, César A Teixeira, Marcelle Rodrigues, Felipe D Machado, Ana Paula Ornaghi, Ana Paula D de Souza, Fabio Maito, Wander R Pavanelli, João S Silva, Cristina Bonorino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2999527?pdf=render

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http://europepmc.org/articles/PMC2999527?pdf=render

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