Valproic acid blocks excitability in SMA type I mouse motor neurons

Valproic acid blocks excitability in SMA type I mouse motor neurons

Valproic acid (VPA), an antiepileptic drug and HDAC inhibitor, has been identified as a drug candidate for spinal muscular atrophy (SMA), a motoneuron disorder for which currently no effective therapy is available. Based on its potential to up-regulate SMN expression from the SMN2 gene in fibroblast...

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Bibliographic Details
Main Authors: Kristen Rak, Barbara Dorothea Lechner, Christine Schneider, Hans Drexl, Michael Sendtner, Sibylle Jablonka
Format: Article
Language:English
Published: Elsevier 2009-12-01
Series:Neurobiology of Disease
Subjects:
Spinal muscular atrophy
Valproic acid
HDAC
Motoneuron
Excitability
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002411

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http://www.sciencedirect.com/science/article/pii/S0969996109002411

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