Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating β1-Integrin/FAK Signaling

Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating β1-Integrin/FAK Signaling

Bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) is a natural bromophenol compound derived from marine algae. Previous reports have shown that BDDPM possesses antimicrobial activity. In the present study, we found that BDDPM has cytotoxic activity on a wide range of tumor cells, including BEL...

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Bibliographic Details
Main Authors: Ning Wu, Jiao Luo, Bo Jiang, Lijun Wang, Shuaiyu Wang, Changhui Wang, Changqing Fu, Jian Li, Dayong Shi
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:Marine Drugs
Subjects:
bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM)
anti-metastatic activity
cell adhesion
β1-integrin
FAK
BEL-7402 cell
Online Access:http://www.mdpi.com/1660-3397/13/2/1010

Internet

http://www.mdpi.com/1660-3397/13/2/1010

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