Arthroscopic “Debridement and Implant Retention” With Local Administration of Exebacase (Lysin CF-301) Followed by Suppressive Tedizolid as Salvage Therapy in Elderly Patients for Relapsing Multidrug-Resistant S. epidermidis Prosthetic Knee Infection

Arthroscopic “Debridement and Implant Retention” With Local Administration of Exebacase (Lysin CF-301) Followed by Suppressive Tedizolid as Salvage Therapy in Elderly Patients for Relapsing Multidrug-Resistant S. epidermidis Prosthetic Knee Infection

Exebacase, a recombinantly produced lysin has recently (i) reported proof-of-concept data from a phase II study in S. aureus bacteremia and (ii) demonstrated antibiofilm activity in vitro against S. epidermidis. In patients with relapsing multidrug-resistant (MDR) S. epidermidis prosthetic knee infe...

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Bibliographic Details
Main Authors: Tristan Ferry, Cécile Batailler, Aubin Souche, Cara Cassino, Christian Chidiac, Thomas Perpoint, Claire le Corvaisier, Jérôme Josse, Romain Gaillard, Julien Roger, Camille Kolenda, Sébastien Lustig, Frédéric Laurent, The Lyon BJI Study Group
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Medicine
Subjects:
lysin
prosthetic-joint infection
tedizolid
staphylococci
S. epidermidis
bacteriophage
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.550853/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.550853/full

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