The polymyxin B-induced transcriptomic response of a clinical, multidrug-resistant Klebsiella pneumoniae involves multiple regulatory elements and intracellular targets

The polymyxin B-induced transcriptomic response of a clinical, multidrug-resistant Klebsiella pneumoniae involves multiple regulatory elements and intracellular targets

Abstract Background The emergence of multidrug-resistant Klebsiella pneumoniae is a major public health concern. Many K. pneumoniae infections can only be treated when resorting to last-line drugs such as polymyxin B (PB). However, resistance to this antibiotic is also observed, although insufficien...

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Bibliographic Details
Main Authors: Pablo Ivan Pereira Ramos, Márlon Grégori Flores Custódio, Guadalupe del Rosario Quispe Saji, Thiago Cardoso, Gisele Lucchetti da Silva, Graziela Braun, Willames M. B. S. Martins, Raquel Girardello, Ana Tereza Ribeiro de Vasconcelos, Elmer Fernández, Ana Cristina Gales, Marisa Fabiana Nicolás
Format: Article
Language:English
Published: BMC 2016-10-01
Series:BMC Genomics
Subjects:
Antibiotic resistance
Klebsiella pneumoniae
Pathogen
Polymyxin B
RNA-seq
Transcriptomics
Online Access:http://link.springer.com/article/10.1186/s12864-016-3070-y

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http://link.springer.com/article/10.1186/s12864-016-3070-y

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