Spinal cord atrophy in a primary progressive multiple sclerosis trial: Improved sample size using GBSI

Spinal cord atrophy in a primary progressive multiple sclerosis trial: Improved sample size using GBSI

Background: We aimed to evaluate the implications for clinical trial design of the generalised boundary-shift integral (GBSI) for spinal cord atrophy measurement. Methods: We included 220 primary-progressive multiple sclerosis patients from a phase 2 clinical trial, with baseline and week-48 3DT1-we...

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Bibliographic Details
Main Authors: Marcello Moccia, Nicola Valsecchi, Olga Ciccarelli, Ronald Van Schijndel, Frederik Barkhof, Ferran Prados
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:NeuroImage: Clinical
Subjects:
Multiple sclerosis
Spinal cord
Atrophy
Clinical trial
GBSI
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158220302552

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http://www.sciencedirect.com/science/article/pii/S2213158220302552

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