UPLC-MS/MS for simultaneous quantification of vortioxetine and its metabolite Lu AA34443 in rat plasma and its application to drug interactions

UPLC-MS/MS for simultaneous quantification of vortioxetine and its metabolite Lu AA34443 in rat plasma and its application to drug interactions

Vortioxetine is currently used as the first-line therapy drug for major depressive disorder (MDD). In the present study, we aimed to develop and fully validate an ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous quantification of vortioxetine...

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Bibliographic Details
Main Authors: Er-Min Gu, Yuanyuan Shao, Wei-Feng Xu, Lei Ye, Ren-ai Xu
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Arabian Journal of Chemistry
Subjects:
Vortioxetine
Lu AA34443
Pharmacokinetic interaction
UPLC-MS/MS
Inhibitory effect
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535220303907

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http://www.sciencedirect.com/science/article/pii/S1878535220303907

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