Functional Inhibitory Siglec-6 Is Upregulated in Human Colorectal Cancer-Associated Mast Cells

Functional Inhibitory Siglec-6 Is Upregulated in Human Colorectal Cancer-Associated Mast Cells

Mast cells (MC) accumulate in colorectal cancer (CRC) and the relationship between MC density and cancer progression has been well recognized. MC can be either pro-tumor or anti-tumor players, depending on the local factors present in the tumor microenvironment. Upon malignant transformation, cancer...

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Bibliographic Details
Main Authors: Yingxin Yu, Bart R. J. Blokhuis, Mara A. P. Diks, Ali Keshavarzian, Johan Garssen, Frank A. Redegeld
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
Siglec-6
human mast cells
immunoreceptor tyrosine-based inhibitory motif
colorectal cancer
hypoxia
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02138/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02138/full

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