Pyrinap ligands for enantioselective syntheses of amines

Chiral amines find use as chiral ligands, resolving reagents and versatile building blocks as well as in pharmaceuticals and agrochemicals. Here, the authors developed Pyrinap ligands for the copper-catalyzed enantioselective A3-coupling of terminal alkynes, aldehydes, and amines affording optically...

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Bibliographic Details
Main Authors: Qi Liu, Haibo Xu, Yuling Li, Yuan Yao, Xue Zhang, Yinlong Guo, Shengming Ma
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20205-0