Osthole improves function of periodontitis periodontal ligament stem cells via epigenetic modification in cell sheets engineering

Abstract Inflammatory microenvironment causes the change of epigenetic modification in periodontal ligament stem cells derived from periodontitis tissues (P-PDLSCs), which results in defective osteogenic differentiation compared to cells from healthy tissues. It’s urgent to explore therapeutic strat...

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Bibliographic Details
Main Authors: Jin Sun, Zhiwei Dong, Yang Zhang, Xiaoning He, Dongdong Fei, Fang Jin, Lin Yuan, Bei Li, Yan Jin
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05762-7