Xenocoumacin 2 reduces protein biosynthesis and inhibits inflammatory and angiogenesis-related processes in endothelial cells

Xenocoumacin 2 reduces protein biosynthesis and inhibits inflammatory and angiogenesis-related processes in endothelial cells

Xenocoumacin (Xcn) 1 and 2 are the major antibiotics produced by the insect-pathogenic bacterium Xenorhabdus nematophila. Although the antimicrobial activity of Xcns has been explored, research regarding their action on mammalian cells is lacking. We aimed to investigate the action of Xcns in the co...

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Bibliographic Details
Main Authors: Pelin Erkoc, Michaela Schmitt, Rebecca Ingelfinger, Iris Bischoff-Kont, Larissa Kopp, Helge B. Bode, Susanne Schiffmann, Robert Fürst
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Natural products
Xenocoumacin
Endothelial cells
Leukocytes
Inflammation
Angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221005473

Internet

http://www.sciencedirect.com/science/article/pii/S0753332221005473

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