Calibrating the Bacterial Growth Rate Speedometer: A Re-evaluation of the Relationship Between Basal ppGpp, Growth, and RNA Synthesis in Escherichia coli

Calibrating the Bacterial Growth Rate Speedometer: A Re-evaluation of the Relationship Between Basal ppGpp, Growth, and RNA Synthesis in Escherichia coli

The molecule guanosine tetraphophosphate (ppGpp) is most commonly considered an alarmone produced during acute stress. However, ppGpp is also present at low concentrations during steady-state growth. Whether ppGpp controls the same cellular targets at both low and high concentrations remains an open...

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Bibliographic Details
Main Authors: Nicole C. E. Imholz, Marek J. Noga, Niels J. F. van den Broek, Gregory Bokinsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Microbiology
Subjects:
ppGpp
growth rate
RNA polymerase
RNA synthesis
Escherichia coli
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.574872/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.574872/full

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