Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

Abstract Background Mammographic breast density, adjusted for age and body mass index, and a polygenic risk score (PRS), comprised of common genetic variation, are both strong risk factors for breast cancer and increase discrimination of risk models. Understanding their joint contribution will be im...

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Bibliographic Details
Main Authors: Celine M. Vachon, Christopher G. Scott, Rulla M. Tamimi, Deborah J. Thompson, Peter A. Fasching, Jennifer Stone, Melissa C. Southey, Stacey Winham, Sara Lindström, Jenna Lilyquist, Graham G. Giles, Roger L. Milne, Robert J. MacInnis, Laura Baglietto, Jingmei Li, Kamila Czene, Manjeet K. Bolla, Qin Wang, Joe Dennis, Lothar Haeberle, Mikael Eriksson, Peter Kraft, Robert Luben, Nick Wareham, Janet E. Olson, Aaron Norman, Eric C. Polley, Gertraud Maskarinec, Loic Le Marchand, Christopher A. Haiman, John L. Hopper, Fergus J. Couch, Douglas F. Easton, Per Hall, Nilanjan Chatterjee, Montse Garcia-Closas
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Breast Cancer Research
Subjects:
Breast density
Breast cancer risk
Polygenic risk score
Genetic variation
Risk models
Online Access:http://link.springer.com/article/10.1186/s13058-019-1138-8

Internet

http://link.springer.com/article/10.1186/s13058-019-1138-8

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