Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

Missense mutations in the multi-domain kinase LRRK2 cause late onset familial Parkinson's disease. They most commonly with classic proteinopathy in the form of Lewy bodies and Lewy neurites comprised of insoluble α-synuclein, but in rare cases can also manifest tauopathy. The normal function of...

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Bibliographic Details
Main Authors: Jason Schapansky, Saurabh Khasnavis, Mark P. DeAndrade, Jonathan D. Nardozzi, Samuel R. Falkson, Justin D. Boyd, John B. Sanderson, Tim Bartels, Heather L. Melrose, Matthew J. LaVoie
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Neurobiology of Disease
Subjects:
LRRK2
α-Synuclein
Tau
Tau phosphorylation
Lysosome
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302838

Internet

http://www.sciencedirect.com/science/article/pii/S0969996117302838

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