Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model.

Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model.

Cytokines such as TNFα can polarize microglia/macrophages into different neuroinflammatory types. Skewing of the phenotype towards a cytotoxic state is thought to impair phagocytosis and has been described in Alzheimer's Disease (AD). Neuroinflammation can be perpetuated by a cycle of increasin...

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Bibliographic Details
Main Authors: S Prasad Gabbita, Ming F Johnson, Naomi Kobritz, Pirooz Eslami, Aleksandra Poteshkina, Sridhar Varadarajan, John Turman, Frank Zemlan, Marni E Harris-White
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4593589?pdf=render

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http://europepmc.org/articles/PMC4593589?pdf=render

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