Inhibition of Caspase-1 Ameliorates Ischemia-Associated Blood-Brain Barrier Dysfunction and Integrity by Suppressing Pyroptosis Activation

Inhibition of Caspase-1 Ameliorates Ischemia-Associated Blood-Brain Barrier Dysfunction and Integrity by Suppressing Pyroptosis Activation

Ischemic cerebral infarction represents a significant cause of disability and death worldwide. Caspase-1 is activated by the NLRP3/ASC pathway and inflammasomes, thus triggering pyroptosis, a programmed cell death. In particular, this death is mediated by gasdermin D (GSDMD), which induces secretion...

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Bibliographic Details
Main Authors: Yubin Liang, Pingping Song, Wei Chen, Xuemin Xie, Rixin Luo, Jiehua Su, Yunhui Zhu, Jiamin Xu, Rongrong Liu, Peizhi Zhu, Yusheng Zhang, Min Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ischemic stroke
caspase-1
blood-brain barrier
pyroptosis
RAGE
MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.540669/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2020.540669/full

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