Hypoxia-Inducible Factor Is Critical for Pathogenesis and Regulation of Immune Cell Functions in Rheumatoid Arthritis

Hypoxia-Inducible Factor Is Critical for Pathogenesis and Regulation of Immune Cell Functions in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a common autoimmune disease with characteristics of synovial inflammation, pannus formation, cartilage destruction, and bone erosion. Further, the inflammation is linked to increased oxygen consumption, resulting in hypoxia within the inflammatory area. Hypoxia-inducible...

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Bibliographic Details
Main Authors: Xin Guo, Guangjie Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
hypoxia
hypoxia-inducible factor
rheumatoid arthritis
inflammation
pannus formation
cartilage destruction
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01668/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01668/full

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