Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines.

Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines.

Three-dimensional (3D) tumor cell cultures grown in laminin-rich-extracellular matrix (lrECM) are considered to reflect human tumors more realistic as compared to cells grown as monolayer on plastic. Here, we systematically investigated the impact of ECM on phenotype, gene expression, EGFR signaling...

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Bibliographic Details
Main Authors: Anna C Luca, Sabrina Mersch, René Deenen, Stephan Schmidt, Isabelle Messner, Karl-Ludwig Schäfer, Stephan E Baldus, Wolfgang Huckenbeck, Roland P Piekorz, Wolfram T Knoefel, Andreas Krieg, Nikolas H Stoecklein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3608563?pdf=render

Internet

http://europepmc.org/articles/PMC3608563?pdf=render

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