Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation

Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation

Abstract Background Tumor necrosis factor (TNF) is associated with several neurodegenerative disorders including multiple sclerosis (MS). Although TNF-targeted therapies have been largely unsuccessful in MS, recent preclinical data suggests selective soluble TNF inhibition can promote remyelination....

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Bibliographic Details
Main Authors: Alice Valentin-Torres, Carine Savarin, Joslyn Barnett, Cornelia C. Bergmann
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Neuroinflammation
Subjects:
Progressive multiple sclerosis
Experimental autoimmune encephalomyelitis
Tumor necrosis factor
Astrocytes
Oligodendrocytes
Endothelin-1
Online Access:http://link.springer.com/article/10.1186/s12974-018-1164-y

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http://link.springer.com/article/10.1186/s12974-018-1164-y

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