Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats

Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats

Abstract Background Folate receptor-β (FR-β) is a cell surface receptor that is significantly upregulated on activated macrophages during inflammation and provides a potential target for folate-based therapeutic and diagnostic agents. FR-β expression in central nervous system inflammation remains re...

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Bibliographic Details
Main Authors: Petri Elo, Xiang-Guo Li, Heidi Liljenbäck, Semi Helin, Jarmo Teuho, Kalle Koskensalo, Virva Saunavaara, Päivi Marjamäki, Vesa Oikonen, Jenni Virta, Qingshou Chen, Philip S. Low, Juhani Knuuti, Sirpa Jalkanen, Laura Airas, Anne Roivainen
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
Folate receptor
Experimental autoimmune encephalomyelitis
Inflammation
Positron emission tomography
Macrophages
Online Access:https://doi.org/10.1186/s12974-019-1612-3

Internet

https://doi.org/10.1186/s12974-019-1612-3

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